Cyclomine is a drug used to treat certain types of stomach issues called irritable bowel syndrome (IBS) which include diarrhea, constipation and abdominal cramps. Its generic name is Dicyclomine. It is usually branded as Bentyl, Dibent, Dicyclocot. It can be administered intramuscularly and orally in a capsule, syrup or tablet. Cyclomine belongs to a class of drugs known as anticholinergics/antispasmodics. Anticholinergics are drugs that block the action of acetylcholine. Acetylcholine is a neurotransmitter that transfers signals between specific cells to affect how your body functions. This drug works by slowing down the natural movement of the guts and relaxing the muscles in the stomach and intestines.


This medication is usually taken orally in a tablet or syrup. The dosage taken is based on age, medical condition, and response to treatment. It can be taken with or without food. Nonetheless, following a doctor’s prescription is usually taken four (4) times daily. The syrup should be carefully measured with a measuring device. Antacids lower the absorption of Dicyclomine. Therefore, it is advisable to take an antacid after meals and take Dicyclomine before meals. Always seek your doctor’s approval before increasing or lowering the dosage.

The following are the side effects of using Dicyclomine. They include; dizziness, drowsiness, lightheadedness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating. If these effects persists or worsen, consult your doctor or pharmacist immediately.
Before taking cyclomine, tell your doctor or pharmacist if you are allergic to it; or have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.Before you take this medication, tell your doctor or pharmacist if you have any of this:
  • Personal or family history of glaucoma
  • Enlarged prostate
  • Problems with urination due to blocked urinary tract
  • Infection
  • Little/no stomach acid
  • Overactive thyroid
  • Heart problems e.g. coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding.
  • Certain nervous system problem
  • Liver problems
  • Kidney problems
This medication can make someone sweat less, making you more likely to get heatstroke due to heat not being released from the body.This drug should be used only when needed during pregnancy. Even at that, consult your doctor. This drug can pass into breast milk for nursing, causing undesirable effects on an infant. Therefore, do not use this drug while breastfeeding.
Drug interactions change how medications work or increase the risk for serious side effects. The following are products that may interact with this drug:
  • Potassium tablets/capsules, drugs that are affected by slowed gut movement such as pramlintide.
  • Certain azole anti-fungal drugs’ absorption may be affected by cyclomine. Examples of such drugs are ketoconazole, itraconazole. If you are taking drugs such as these, take those two (2) hours before cyclomine.
  • Drugs that cause dry mouth and constipation.
  • Other anticholinergic drugs such as atropine, glycopyrrolate and scopolamine and antispasmodic drugs such as clidinium, propantheline.
  • Certain drugs are used for Parkinson's disease, such as trihexyphenidyl.
  • Certain drugs used to treat irregular heart rhythms, such as disopyramide, quinidine.
  • MAO inhibitors include isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine.
  • Phenothiazines such as chlorpromazine.
  • Tricyclic antidepressants such as amitriptyline.
If you take products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines such as cetirizine and diphenhydramine, drugs for sleep and anxiety such as alprazolam, diazepam, and zolpidem, always consult your doctor or pharmacist. Some muscle relaxants and opioid pain relievers can also interact with it.Always check the label on all your medicines and discuss with your doctors before usage.This medication can also interfere with certain laboratory tests including gastric secretion tests which can make the test results false. Make sure to inform laboratory personnel and doctors.
If someone overdosed and has severe symptoms such as passing out or trouble breathing, call for emergency immediately. Symptoms of overdose may include: large pupils, hot/dry skin, fever, fast/irregular heartbeat, muscle weakness, inability to move, slowed breathing, severe dizziness, fainting, severe thirst, difficulty swallowing, seizures, and mood changes.

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