Duphaston is the brand name of the drug dydrogesterone. It is a progestin medication that is used for a variety of indications. These include threatened or recurrent miscarriage during pregnancy, dysfunctional bleeding, and infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhea, irregular cycles, and premenstrual syndrome and as a component menopausal hormone therapy.

Duphaston contains progestin (female hormone) that plays a significant role in regulating the menstrual cycles in females. It initiates the average, regular growth and shedding of the womb lining. This helps induce regular periods in women with menstrual irregularities due to a lack of progesterone. Moreover, it relieves painful or absent periods, facilitates egg implantation, and thus, treats infertility.

In the treatment of infertility, Duphaston prepares the womb lining for pregnancy. It increases the chances of a successful pregnancy in women who have a history of recurrent abortions. In the treatment of endometriosis, Duphaston prevents the growth of the endometrial tissue outside the uterus and thus helps relieve the symptoms you may have. It is administered orally.


Duphaston is a medication that will be prescribed to you depending on the condition you are being treated for. Do not self-medicate. Your doctor will decide the duration and dosage after some investigations like blood tests, ultrasonography, etc. the drug should always be taken at the same time every day. Swallow it whole, without breaking or chewing, preferably with a glass of water. It may be taken with or without food.

Side effects of Duphaston include menstrual irregularities, headache, vomiting nausea, breast tenderness, breast pain, stomach pain, migraine, vaginal bleeding, and others. Ask your doctor about dealing with these and what you can do to prevent them. If they still do not get better or worsen, consult your doctor on a further course of action.

Patients should always discuss any previous medical history like diabetes, depression, heart or liver disease with the doctor before using Duphaston. Also, other medicines should be brought to the doctor’s notice as they can interfere with the drug or make it less effective. Pregnant and breastfeeding mothers should not take this drug without discussing it with the doctor first.

You should not take Duphaston along with:

  • Epilepsy medicines like phenobarbital, phenytoin, and carbamazepine.
  • Medications like rifampicin and rifabutin (used in tuberculosis).
  • When taking the medicine, you should not consume herbal preparations containing, e.g. St John's Wort (Hypericum perforatum), sage, or Ginkgo Biloba.
  • Medicines like ritonavir, nelfinavir, nevirapine, and efavirenz (used in HIV).

Some medicines may affect the way Duphaston tablet works, or the treatment itself can reduce the effectiveness of other medications taken at the same time.

Tell the doctor about the medicines, supplements, or herbals you are currently taking or might take to avoid possible interaction.

There is no sufficient clinical data to support overdose in humans. The maximum dose of dydrogesterone administered to humans to date is 360mg orally and the medication was found to be well tolerated at this dose. There is no antidotes to overdose as treatments should be based on symptoms. If you miss a dose, take it as soon as you remember otherwise if the next dose is close, take the next dose without the previously missed one.

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