Overview
NAME, BRAND NAME, FORM, STRENGTH, NAFDAC NUMBER, AND DISTRIBUTION OF IBUPROFEN
| NAME | BRAND NAME | FORM | STRENGTH | NAFDAC NUMBER | DISTRIBUTION |
| Makupar | Goldmoore International Ltd | Tablet | 200mg | N/A | N/A |
| Zabumol | Zadip Pharma Nig Ltd | Capsule | 200mg + 325mg + 30mg | N/A | N/A |
| Algafen | Evans Baroque Ltd | Tablet | 4300mg | A11-0942 | N/A |
| Babuflam | Jawa International Limited | Oral suspension | 100mg/5ml | A11-0307 | Over the counter |
| Clean Health Ibuprofen | Clean Health Nig Ltd | Tablet | 400mg | B4-7029 | Prescription-only medicine |
| Ibuprofen (WMF 2.1) | Formulary (WHO) | Tablet | 400mg | N/A | N/A |
| Ibuglox | E-Globa Pharma GMBH Ltd | Tablet | 400mg | B4-6096 | N/A |
PHARMACOVIGILANCE
FDA strengthens warning that non-aspirin Non-steroidal Anti-inflammatory drugs (NSAIDs) such as Ibuprofen can cause heart attacks or strokes. The risk is greater with prolonged use and at higher doses. In addition, patients with heart disease or risk factors for it have a greater risk.
INDICATIONS
Illnesses that could point to the use of Ibuprofen include; mild to moderate pain and inflammation, pyrexia, headache, acute migraine attacks, tension headache, pain and inflammation in rheumatic disease, and other musculoskeletal disorders.
ADULT DOSE
The maximum adult dosage daily is 2.4g. However, a doctor’s prescription is available on 8mg
CHILD DOSE
Although not recommended for children under 16years 50mg can be used 3-4 times daily. However, use under a doctor’s prescription is best.
RENAL DOSE
For Oral use only. Medication should be taken once daily at the same time every day with or without food, and doses should not be skipped.
ADMINISTRATION
Ibuprofen can be used with food to minimize stomach upset after use. However, it should be swallowed whole with plenty of fluid and not chewed, broken, crushed, or sucked on to avoid stomach discomfort and throat irritation.
ADVICE TO PATIENT
Ibuprofen may be taken with food if a stomach upset occurs.
CONTRAINDICATION
Allergy to the acetylsalicylic acid constituent of Ibuprofen can lead to hypersensitivity reactions (including asthma) and active peptic ulceration.
RECOMMENDATIONS
In Pregnancy and breastfeeding, NSAIDs should be given only if the maternal benefits outweigh the potential fetal risks, at the lowest effective dose, and for the shortest duration. Ibuprofen should be avoided during the 3rd trimester of pregnancy. Prolonged use should also be avoided. It is considered compatible with breastfeeding. Its short half-life and deficient levels in breast milk make it one of the preferred analgesics or anti-inflammatory drugs during lactation.
PHARMACOLOGY
Ibuprofen, a propionic acid derivative, is a traditional non-steroidal anti-inflammatory drug (NSAID). It has analgesic, anti-inflammatory, and antipyretic activities. It acts primarily through non-selective, reversible inhibition of the cyclooxygenase enzymes COX-1 and COX-2. COX inhibition results in a marked reduction in prostaglandin synthesis. Furthermore, Ibuprofen reversibly inhibits platelet aggregation.
STORAGE RECOMMENDATIONS
Store below 25ºC and keep out of reach of children.
